2. Signaling Pathways
  3. GPCR/G Protein
  4. Guanylate Cyclase
  5. Guanylate Cyclase Modulator

Guanylate Cyclase Modulator

Guanylate Cyclase Modulator (1):

Cat. No. Product Name Effect Purity
  • HY-149453
    MCUF-651
    		Modulator
    MCUF-651 is an orally active guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM) (KD: 397 nM ). MCUF-651 binds to GC-A and selectively enhances the binding of atrial natriuretic peptide (ANP) to GC-A. MCUF-651 enhances ANP-mediated cGMP generation in human cardiac, renal, and fat cells. MCUF-651 inhibits cardiomyocyte hypertrophy.